7-Aminocephalosporanic acid CAS NO.957-68-6

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Float7 - amino silane acid cephalosporin referred to as "7 - ACA, white or white crystalline powder, 7 - ACA is a synthesis of cephalosporin class of antibiotics is important, the parent nucleus in the seven on the parent nucleus with three chemical modification, can produce a lot of cephalosporin class of antibiotics: sodium cefazolin, cefotaxime sodium, sodium, sodium cefazolin pp adit, triazine cephalosporin cefepime he totally sodium, cefuroxime sodium new cephalosporin, etc.

Cephalosporins are a cluster of broad-spectrum semi-synthetic antibiotics, all of which contain the mother nucleus of 7-amino-cephaloanic acid (7-aca). Different groups are added to the carbon atoms at 3 and 7 positions to form various Cephalosporins with different antimicrobial activities and pharmacokinetic properties.Cephalosporin antibiotics have the advantages of broad antibacterial spectrum, strong antibacterial effect, less allergic reaction, partial cross-allergenicity with penicillin and different degrees of stability to -lactamase.Cephalosporins have a rapid development and a large number of families. They are divided into four generations according to the "generation" of anti-microbial activity.

Like penicillin, cephalosporins contain lactam rings, which are necessary for antimicrobial efficacy.However, the penicillin class is all derivatives of 6-aminopenicillanic acid (6-apa), while the mother nucleus of cephalosporin class is 7-aminocephalosporamic acid (7-aca), which comes from Cephalosporium acremonium.

The 7-amino-cephalosporic acid has A dihydrothiazide ring (A) and -lactam ring (B) that are resistant to penicillin-producing enzymes such as staphylococcus.The whole series of cephalosporins were formed by modifying the nucleus with different side chains.Lactamase modification at 7 (R1) alters antimicrobial activity and stability of lactamase.The effect on drug metabolism and pharmacokinetic properties of dihydrothiazide ring at position 3 (R2) was more significant than that of antibacterial activity.

Cephalosporins are chemically related to cephalosporin C, with the main difference being the presence of a 7--methoxygroup (R3), which increases the stability of cephalosporins to some lactamases.Cephalosporin is a derivative of cephalosporin C produced by Streptomyces lactam.Ceftitan is a semi-synthetic derivative of organomycin G and a product of Streptomyces organonensis.Cefomeprazole is a semisynthetic of 7- aminophenoalkanic acid.Ng program Catfish Feed