4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione CAS NO.865854-05-3

1,we produce and sell good chemicals around the world.

2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.

3,our staff consists of highly qualified individuals with bsc, msc and ph.d degrees in chemistry, as well as excellent carbohydrates,nucleosides, small molecules and rare chemicals.

4,imaginechem's chemists are skilled at performing complex, multi-step syntheses and solving difficult chemistry-related problems. because of our better, concentracted size and low overheads, we are able to offer prompt quotations, very competitive prices, high quality products and fast delivery.

5,all chemicals are typically >97% for building blocks, the structure and purity is confirmed by nmr and lc-ms. intermediates and final products are analyzed by gc, hplc, ir, nmr, ms, elemental analysis, atom-absorpting analysis and crystallographical methods.

11,customers-oriented strategy, exclusive supply chain management, professional r&d team, experienced production workers, energetic sales team enable us to offer best service andgood-value products to all of our customers and gradually reach our final goals: becoming global leading supplier for portable products and solutions.

Bioactive Tideglusib is an irreversible, non-atp-competitive gsk-3 β inhibitor with an IC50 of 60nM. Phase2. In vitro studies, Tideglusib irreversely inhibited GSK-3 in human neuroblastoma cells and primary mouse neurons, thereby reducing the level of tau protein phosphorylation and preventing cell apoptosis. Tideglusib(2.5μM) inhibited glutamate-induced glial activation, as evidenced by decreased TNF-α and COX-2 expression levels in rat primary astrocytes or microglias. Tideglusib(2.5μM) also had a protective effect on cortical neurons, protecting them from glutamate-induced neuroexcitatory toxicity. Evidence for this conclusion is that Annexin-VChemicalbook positive cells in primary astrocytes or microglia of rats are significantly reduced in vivo. In vivo studies, Tideglusib(50mg/kg) injected into the hippocampus of adult male Wistar rats can significantly reduce erythrocystine induced inflammatory response and damage to the hippocampus The area is protective. In APP/tau mice, Tideglusib(200mg/kg, orally) reduced tau phosphorylation, amyloid deposition and plus-associated astrocyte proliferation. Bioactive Tideglusib(NP031112, np-12) is an irreversible, non-atp-competitive gsk-3 β inhibitor with IC50 of 60nM in cell-free trials. Cys kinases co-derived from CYS-199 at the active site were not inhibited. Phase2.