trihydroxyethylrutin CAS NO.7085-55-4

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Troxerutin (chemical name 7,3,4, -tri (O-(2-hydroxyhexyl)) rutin, which is the mixture of hydroxyethyl rutin obtained by hydroxyethyl ethylation, is yellow, yellow-green or light brown yellow powder, odorless, slightly salty, with moisture attractant, and the main hydrolytic product is hypericin.Troxrutin is a semi-synthetic flavonoid compound made by hydroxyethylation of rutin.It can inhibit red blood cells and platelets agglutination, increase blood oxygen content, improve microcirculation, and promote the formation of new blood vessels. It is a good drug to protect endothelial cells and treat acute ischemic brain injury.And has the effect of anti-radiation damage, anti-inflammation, anti-allergy, anti-ulcer and so on.It is the main component of Vitenolutong and is often used in tablets and injections.Pharmacological action trixrutin can inhibit platelet aggregation, has the effect of preventing thrombosis.At the same time, it can resist the vascular damage caused by 5-hydroxytryptamine and bradykinin, increase capillary resistance, reduce capillary permeability, and prevent edema caused by increased vascular permeability.It is applicable to the treatment of hemiplegia caused by cerebral thrombosis, aphasia, arteriosclerosis, thrombophlebitis, varicose veins, chronic venous insufficiency, central retinitis, diabetic retinitis and edema caused by increased vascular permeability, etc.Test method of the traditional detection method of rutin QuKe spectrophotometric method, chromatography, flow injection chemiluminescence method, capillary electrophoresis method, can also use the cyclic voltammetry to histidine modified in graphene/glassy carbon electrode surface, made from poly (l-histidine graphene glassy carbon electrode, electrode for electrochemical hydrolysate rutin QuKe Chemicalbook detection, the experimental results show that under optimal conditions, the modified electrodes to QuKe rutin hydrolysate have significant electrical catalysis, the oxidation peak current with concentration in 2.0 x 10 -, 4.0 x10-4 tool, L had a good linear relationship within the scope of,The correlation coefficient was R= 0.9996, and the detection limit was 1.25 xl0 1 mol•L ~.This method can be applied to the determination of actual samples.The production method of troxerutin can be made into suitable soft material with starch as filling agent and 95% ethanol as wetting agent, then granulated, dried and then whole granulated with nylon sieve bottom, mixed evenly with magnesium stearate and talc powder as lubricant, and then pressed.Its appearance is bright, delicate, good hardness of tablets, tablets weight difference stable, qualified content.Through this process, the fluidity and outflow velocity of troxrutin powder can be improved, and the outflow velocity of particles can be uniform, thus ensuring the stability of sheet difference. At the same time, the granulation can reduce the amount of fine powder, reduce the chance of powder contacting with punching rod, and avoid the occurrence of die drawing phenomenon.This process does not need to dry less energy, low cost, suitable for industrial production.Analgesic mechanisms QuKe rutin is water-soluble derivatives of rutin, similar to those of rutin and quercetin, while the mother nucleus quercetin and some other with quercetin glycosides of the parent nucleus (such as rutin, st John's wort glucoside, etc.) have significant central and peripheral analgesic action, and its analgesic mechanism related to reduce the content of calcium ion nerve tissue.Therefore, we speculated that the analgesic mechanism of troxerutin may also be related to calcium antagonism.Troxerutin, a water-soluble derivative of rutin, has similar pharmacological effects and higher biological availability, but is more difficult to enter the central nervous system than rutin.This may be the reason for the specificity of troxerutin's analgesic effect