Hydrocortisone CAS NO.50-23-7

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Chemical white or white - like crystalline powder, odorless, bitter taste.Light metamorphoses.Mp214-220 ℃ (decomposition);Polarimetric [alpha] 25 d + 157.5 ° (2 4-dioxane), + 176 ° (chloroform), + + 169 ° 162 ° (ethanol);The ethanol solution has the maximum absorption at the wavelength of 242nm.Insoluble in water, insoluble in ether, slightly soluble in chloroform, soluble in acetone, ethanol.Soluble in concentrated sulfuric acid and green fluorescence.LD50 (rat, abdominal cavity)150mg/kg.

Use of biochemical research, adrenal cortical hormone drugs.

Usage glucocorticoid has four functions of anti - inflammation, anti - allergy, anti - toxin and anti - shock.

Use for adrenal cortical hormone drugs

Use the adrenal cortex produces the main glucocorticoid, which is three times more powerful than the corticosterone.

Production methods: 4-progesterene-17a, 21-diol-3, 20-diket-21-acetate (acetic acid compound "S") was oxidized by microorganism of Absidia Orchidis 3.65, and hydrocortisone was obtained by extraction, separation and purification with a yield of 44%.

The production method: cordnisone acetate is prepared by condensation of urea, reduction of potassium borohydride, treatment with sodium nitrite and hydrochloric acid