Chlorogenic acid CAS NO.327-97-9

Chlorogenic acid which is also called "green" auspicious acid, tannins "coffee", "coffee tannic acid", is a plant of shikimic acid hitches in aerobic respiration process a styrene acrylic compounds, for coffee acyl quinic acid derivatives, the oxidation resistance is strong, also has the anti HIV, anti tumor cells, antibacterial, improve central excited, cholagogue function, teratogenic, allergy and regulate the activity of cytochrome P450 ligase, and other functions.

It is widely found in many honeysuckle plants.By the water needle crystal, for the hemihydrate, 110 ℃ to hydrate.Melting point 208 ℃, [alpha] D25 33.5 ° (water, C = 1), K = 2.2 x 10-3 (27 ℃).It has a weak acid taste and convergence.25 ℃ when the solubility in water is 4%, easily soluble in hot water, but soluble in ethanol, acetone, slightly soluble in ethyl acetate, insoluble in chloroform, ether and carbon disulfide.Azeotropic blue dye with concentrated hydrochloric acid.Can make the bromine water fade, with strong hydrogen iodide azeotropic acid, together with thermal decomposition of phenol water at 230 ℃, with dilute hydrochloric acid decomposition of caffeic acid and quinic acid, etc., at room temperature and dilute alkali caffeic acid and quinic acid.Chlorogenic acid and its isomers, isochlorogenic acid and neochlorogenic acid, are also found in fruits, leaves and other tissues of dicotyledonous plants and are important factors for plant metabolism.Chlorogenic acid has good biological activity, inhibits hyaluronidase and glucose-6-phosphatase, has special effect on free radical scavenging, anti-lipid peroxidation, anti-mutagenesis, cardiovascular crown enlargement and lipid-lowering, and has antibacterial and antivirus effects as well as liver and gallbladder protection.

Chlorogenic acid is a condensation of caffeic acid and quinine acid. It is blue when it meets iron and similar to tannin, but does not precipitate protein, so it has no convergence effect.Caffeic acid and chlorogenic acid have extensive bacteriostasis, but can be inactivated by protein in vivo.Similar to caffeine, this product can enhance central excitability of rats by oral or intraperitoneal injection.Chlorogenic acid and caffeic acid oral, can increase the amount of hydrochloric acid secretion in the human stomach, and can make the pulse slow, and quinine acid is not.Chlorogenic acid significantly increased peristasis in the small intestine of rats or mice, while chlorogenic acid, caffeic acid and quinine acid all increased uterine tension in rats.Caffeic acid and chlorogenic acid also increased bile secretion in rats.In isolated rabbit ileum, this product can enhance the effect of epinephrine, but has no effect on the effect of epinephrine on blood glucose.