Metronidazole high purity CAS NO.443-48-1

Metronidazole is a kind of nitro imidazoles antibiotics, also called metronidazole, a nitrate da etc, a nitro hydroxy ethyl azole, destroyed drop, the anaerobic microorganisms has the effect to kill, it generated metabolites in reduction in the human body also has an anaerobic bacteria, inhibiting bacteria deoxyribonucleic acid synthesis, which interfere with the bacterial growth, reproduction, eventually kill bacteria, anaerobic bacteria resistance, including: bacteroides fragilis, spindle coli (due to bacteria form sharp on both ends is named spindle), tetanus, digestive bacteria staphylococcus aureus, streptococcus, jia the giardia. Originally used to treat vaginal trichomoniasis, the clinical effect is very significant. Later, it was found that metronidazole could also kill the anaerobic bacteria causing oral infection. In 1978, it was identified by the world health organization as a special drug for anti-anaerobic bacteria infection, which was widely used in the prevention and treatment of oral anaerobic bacteria infection. It is also commonly used in hospitals for the prevention and treatment of respiratory, digestive, abdominal and pelvic infections caused by anaerobic bacteria, skin and soft tissue and bone and joint infections, pericarditis, sepsis and brain treatment.

 

Metronidazole has a significant effect on amoeba disease in vivo tissues and intestinal cavity, and is also the preferred drug for the treatment of insectosis in the human body. The mechanism of action is that the nitrogen chain of protozoa is broken by inhibiting the REDOX reaction of amoeba. In vitro experiment proved that the drug concentration of 1 ~ 2 mg/L, the soluble organization amoeba in morphological change in 6 ~ 20 hours, 24 hours are all kill, concentration of 0.2 mg/L, can kill within 72 hours to dissolve amoeba, has been widely used in the treatment of intestinal and parenteral amebiasis (such as amebic liver abscess and pleural amoebiasis, etc.).

 

Because nitroimidazoles interact with ethanol and nicotine and interfere with the oxidation process of ethanol, they can cause dithiolam reaction, resulting in faster heart rate, lower blood pressure and other symptoms. Therefore, during medication, patients should avoid contact with alcoholic drinks and smoke less to avoid adverse drug reactions. Used in medicine and cosmetics, as an antioxidant, has the effect of preventing cancer and inhibiting virus

 

Common in polyphenols. An inhibitor of glutathione s-transferase, commonly used to detect plasma factor XIIa; Antioxidants; DNA double strand protectant.