Salcaprozate sodium CAS NO.203787-91-1

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Sodium 8-(2-hydroxybenzoyl) octanoate, or SNAC for short, is a bisphosphate compound absorption promoter used in the treatment of gastrointestinal diseases, especially those caused by malabsorption of bisphosphate Chemicalbook. Oral administration of sodium 8-(2-hydroxybenzoyl) octanoate (2.5 mg/d) has been shown to be effective in treating absorption of dicarbophosphate compounds

SNACimprovestheoralabsorptionofbothR1andSAsandenhancesbioavailabilityinrats.SNAC(2000mg/kg/d;oralgavagefor13weeks)relatedmortalityisevidentonlyatthe2000-mg/kg/dlevel,20%amongmalesand50%amongfemales;noclearcauseofdeathisevident.SNAC(100-1000mg/kg/dChemicalbook;oralgavagefor13weeks)inducesnomortalityintheWistarratstudyatdosesupto1000mg/kg/d.AnimalModel:Sprague-Dawleyrats(6-7weeks)Dosage:2000mg/kg/dAdministration:Oralgavagefor13weeksResult:Induced20%and50%mortalityinmalesandfemalesatthedoseof2000mg/kg/d.