Pitavastatin CAS NO.147511-69-1

Min.Order: 1 Metric Ton
Payment Terms: T/T,

Product Details

Keywords

ITAVASTATIN
PitavastatinCa
PITVASTATIN

Quick Details

ProName: Pitavastatin
CasNo: 147511-69-1
Molecular Formula: C25H24FNO4
Appearance: white power
Application: Pharma;Industry;Agricultural;chemical ...
DeliveryTime: 3-5 working days
PackAge: as your requirement
Port: China Main Port
ProductionCapacity: 1000 Metric Ton/Month
Purity: 99%
Storage: Keep it in dry,shady and cool place
Transportation: SEA OR AIR
LimitNum: 1 Metric Ton

Superiority

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2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.

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5,all chemicals are typically >97% for building blocks, the structure and purity is confirmed by nmr and lc-ms. intermediates and final products are analyzed by gc, hplc, ir, nmr, ms, elemental analysis, atom-absorpting analysis and crystallographical methods.

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Details

Pharmacological effects

(1) pivastatin had a strong antagonistic effect on HMG-CoA reductase by inhibiting HMG-CoA reductase. The IC50 value was 6.8 nmol/L, which was 24 times stronger than simvastatin and 68 times stronger than fluvastatin.

(2) blocking the synthesis of cholesterol pivastatin can effectively inhibit the cholesterol production process in human hepatocytes HepG2, with an IC50 value of 5.8 nmol/L, and its action intensity is 29 times that of simvastatin and 57 times that of avastatin. However, the inhibition of pivastatin on various enzymes in the cholesterol production process after the formation of mevalonate was very weak.

(3) increasing LDL receptor density pivastatin can induce the synthesis of LDS receptor mRNA at the ultra-low concentration of 1 microns mol/L, and increase its quantity, leading to the increase of LDL receptor density, thus promoting the removal of LDL, reducing plasma ldl-cholesterol concentration and plasma total triglyceride concentration.

Clinical application

1. Lipid-lowering effect, lowering the level of low-density lipoprotein and triglyceride in the blood can prevent and reverse the occurrence and development of coronary heart disease.

2. Anti-atherosclerosis effect.

3. Promoting angiogenesis.

4. Anti-inflammatory.

5. Activate the high molecular adiponectin in vivo.

6. Anti-oxidative stress.